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Autism, schizophrenia, and bipolar disorder

Autism, schizophrenia, and bipolar disorder


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Disorders like autism, schizophrenia, and bipolar disorder they share a significant number of genes that contribute to their development, according to a study by Columbia University in New York (United States) published in the online edition of the journal Proceedings of the National Academy of Sciences (PNAS).

Researchers have designed a statistical model to quantify the genetic connections between diseases that manifest complex symptoms such as autism, schizophrenia and bipolar disorder.

According to the scientists, led by Andrey Rzhetsky, multiple genetic factors contribute greatly to the likelihood that a patient will develop a complex disorder. The researchers analyzed data from 1.5 million records of patients from the Columbia University Medical Center clinical database. The computer model calculates the genetic overlap between pairs of diseases, that is, the number of genetic aberrations that contribute to both diseases.

The authors, who analyzed 161 conditions, in their analysis paid special attention to Neurological disorders. One of the most prominent discoveries was that there is a significant genetic overlap between autism, schizophrenia, and bipolar disorder. According to the researchers, the model could be useful for those researchers working on the genetic origin of diseases that arise from more than one mutation.

1. Schizophrenia. The term schizophrenia means "split mind." The age of onset is between 15 and 45 years. Although they usually begin at the end of adolescence, there are also cases of onset in childhood, which are often masked by school problems or problems misbehavior.

A person with schizophrenia experiences a distortion of thoughts and feelings. What characterizes schizophrenia is that it affects the person in a total way, and whoever suffers it begins to feel, think and speak differently than they did before. Such a person can begin to isolateYou may avoid going out with friends, sleeping too little or too much, talking to yourself, or laughing for no apparent reason (although these symptoms do not have to appear in all patients).

It is very important not to forget that the person who has schizophrenia cannot explain what is happening to him, you are afraid to do it or to believe that you are sick and, therefore, will not ask for help or complain in most cases about what is happening to you. For all this, most of them and especially at the beginning of the disease do not accept to take medication or go to the specialist.

2. Bipolar disorder. It is a long-standing depressive disorder, in which depressive episodes are interfered with by the appearance of other episodes characterized by an elevated mood (excessive euphoria), expansive (abnormal hyperactivity) or irritable. The phases of exaltation, unbridled joy or irritability and rudeness, alternate with other episodes in which the person is with intense depression, low mood, inability to enjoy, lack of energy, negative ideas and, in severe cases, thoughts of suicide.

3. Autism. It is a maturational disability with a neurological substrate and a genetic component. It can be associated with very different neurobiological disorders and at very varied intellectual levels. Autistics have three general categories of behavioral impairment:

1. Qualitative deterioration of reciprocal social interaction: of the social relationship.
2. Qualitative impairment of language and communication development.
3. Restricted, repetitive and stereotyped modes of behavior, interests and activities. The disorder begins at an early age, usually within the first 3 years of life.

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